Platelet α-granules modulate the inflammatory response under systemic lipopolysaccharide injection in mice.
Identifieur interne : 000304 ( Main/Exploration ); précédent : 000303; suivant : 000305Platelet α-granules modulate the inflammatory response under systemic lipopolysaccharide injection in mice.
Auteurs : Sofiane Tariket [France] ; Jose A. Guerrero [Royaume-Uni] ; Olivier Garraud [France] ; Cedric Ghevaert [Royaume-Uni] ; Fabrice Cognasse [France]Source :
- Transfusion [ 1537-2995 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Dosage immunologique (MeSH), Inflammation (génétique), Inflammation (immunologie), Inflammation (induit chimiquement), Ligand de CD40 (génétique), Ligand de CD40 (métabolisme), Lipopolysaccharides (toxicité), Modèles animaux de maladie humaine (MeSH), Mutation (génétique), Mâle (MeSH), Protéines du sang (génétique), Protéines du sang (métabolisme), Souris (MeSH), Souris de lignée C57BL (MeSH), Souris knockout (MeSH), Syndrome des plaquettes grises (génétique), Syndrome des plaquettes grises (immunologie), Syndrome des plaquettes grises (métabolisme).
- MESH :
- génétique : Inflammation, Ligand de CD40, Mutation, Protéines du sang, Syndrome des plaquettes grises.
- immunologie : Inflammation, Syndrome des plaquettes grises.
- induit chimiquement : Inflammation.
- métabolisme : Ligand de CD40, Protéines du sang, Syndrome des plaquettes grises.
- toxicité : Lipopolysaccharides.
- Animaux, Dosage immunologique, Modèles animaux de maladie humaine, Mâle, Souris, Souris de lignée C57BL, Souris knockout.
English descriptors
- KwdEn :
- Animals (MeSH), Blood Proteins (genetics), Blood Proteins (metabolism), CD40 Ligand (genetics), CD40 Ligand (metabolism), Disease Models, Animal (MeSH), Gray Platelet Syndrome (genetics), Gray Platelet Syndrome (immunology), Gray Platelet Syndrome (metabolism), Immunoassay (MeSH), Inflammation (chemically induced), Inflammation (genetics), Inflammation (immunology), Lipopolysaccharides (toxicity), Male (MeSH), Mice (MeSH), Mice, Inbred C57BL (MeSH), Mice, Knockout (MeSH), Mutation (genetics).
- MESH :
- chemical , genetics : Blood Proteins, CD40 Ligand.
- chemical , metabolism : Blood Proteins, CD40 Ligand.
- chemically induced : Inflammation.
- genetics : Gray Platelet Syndrome, Inflammation, Mutation.
- immunology : Gray Platelet Syndrome, Inflammation.
- metabolism : Gray Platelet Syndrome.
- chemical , toxicity : Lipopolysaccharides.
- Animals, Disease Models, Animal, Immunoassay, Male, Mice, Mice, Inbred C57BL, Mice, Knockout.
Abstract
BACKGROUND
Beyond their role in hemostasis and thrombosis, platelets are also important mediators of inflammation by the release of hundreds of factors stored in their α-granules. Mutations in Nbeal2 cause gray platelet syndrome (GPS), characterized by the lack of platelet α-granules. This study aims to evaluate the immunological (proinflammatory) effects of platelet α-granules.
STUDY DESIGN AND METHODS
We performed an experiment using Nbeal2
RESULTS
The lack of Nbeal2 (in Nbeal2
CONCLUSIONS
These results show that α-granules play a direct role in platelet-mediated inflammation balance, confirming the need to further investigate platelet-associated inflammatory pathophysiology and inflammatory adverse events related to blood transfusion.
DOI: 10.1111/trf.14970
PubMed: 30394544
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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mice.</title><author><name sortKey="Tariket, Sofiane" sort="Tariket, Sofiane" uniqKey="Tariket S" first="Sofiane" last="Tariket">Sofiane Tariket</name><affiliation wicri:level="3"><nlm:affiliation>Université de Lyon, Groupe sur l'Immunité des Muqueuses et Agents Pathogènes (GIMAP)-EA3064, Saint-Etienne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lyon, Groupe sur l'Immunité des Muqueuses et Agents Pathogènes (GIMAP)-EA3064, Saint-Etienne</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Saint-Étienne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Établissement Français du Sang Auvergne-Rhône-Alpes, Saint-Etienne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Établissement Français du Sang Auvergne-Rhône-Alpes, Saint-Etienne</wicri:regionArea><placeName><region 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type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ghevaert, Cedric" sort="Ghevaert, Cedric" uniqKey="Ghevaert C" first="Cedric" last="Ghevaert">Cedric Ghevaert</name><affiliation wicri:level="1"><nlm:affiliation>Department of Haematology, University of Cambridge and National Health Service (NHS) Blood and Transplant, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Cambridge and National Health Service (NHS) Blood and Transplant, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Cognasse, Fabrice" sort="Cognasse, Fabrice" uniqKey="Cognasse F" first="Fabrice" last="Cognasse">Fabrice Cognasse</name><affiliation wicri:level="3"><nlm:affiliation>Université de Lyon, Groupe sur l'Immunité des Muqueuses et Agents Pathogènes (GIMAP)-EA3064, Saint-Etienne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lyon, Groupe sur l'Immunité des Muqueuses et Agents Pathogènes (GIMAP)-EA3064, Saint-Etienne</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Saint-Étienne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Établissement Français du Sang Auvergne-Rhône-Alpes, Saint-Etienne, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Établissement Français du Sang Auvergne-Rhône-Alpes, Saint-Etienne</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Saint-Étienne</settlement></placeName></affiliation></author></analytic><series><title level="j">Transfusion</title><idno type="eISSN">1537-2995</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Blood Proteins (genetics)</term><term>Blood Proteins (metabolism)</term><term>CD40 Ligand (genetics)</term><term>CD40 Ligand (metabolism)</term><term>Disease Models, Animal (MeSH)</term><term>Gray Platelet Syndrome (genetics)</term><term>Gray Platelet Syndrome (immunology)</term><term>Gray Platelet Syndrome (metabolism)</term><term>Immunoassay (MeSH)</term><term>Inflammation (chemically induced)</term><term>Inflammation (genetics)</term><term>Inflammation (immunology)</term><term>Lipopolysaccharides (toxicity)</term><term>Male (MeSH)</term><term>Mice (MeSH)</term><term>Mice, Inbred C57BL (MeSH)</term><term>Mice, Knockout (MeSH)</term><term>Mutation (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Dosage immunologique (MeSH)</term><term>Inflammation (génétique)</term><term>Inflammation (immunologie)</term><term>Inflammation (induit chimiquement)</term><term>Ligand de CD40 (génétique)</term><term>Ligand de CD40 (métabolisme)</term><term>Lipopolysaccharides (toxicité)</term><term>Modèles animaux de maladie humaine (MeSH)</term><term>Mutation (génétique)</term><term>Mâle (MeSH)</term><term>Protéines du sang (génétique)</term><term>Protéines du sang (métabolisme)</term><term>Souris (MeSH)</term><term>Souris de lignée C57BL (MeSH)</term><term>Souris knockout (MeSH)</term><term>Syndrome des plaquettes grises (génétique)</term><term>Syndrome des plaquettes grises (immunologie)</term><term>Syndrome des plaquettes grises (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Blood Proteins</term><term>CD40 Ligand</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Proteins</term><term>CD40 Ligand</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gray Platelet Syndrome</term><term>Inflammation</term><term>Mutation</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Inflammation</term><term>Ligand de CD40</term><term>Mutation</term><term>Protéines du sang</term><term>Syndrome des plaquettes grises</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Inflammation</term><term>Syndrome des plaquettes grises</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Gray Platelet Syndrome</term><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Gray Platelet Syndrome</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Ligand de CD40</term><term>Protéines du sang</term><term>Syndrome des plaquettes grises</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Lipopolysaccharides</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Lipopolysaccharides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Immunoassay</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Dosage immunologique</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris knockout</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Beyond their role in hemostasis and thrombosis, platelets are also important mediators of inflammation by the release of hundreds of factors stored in their α-granules. Mutations in Nbeal2 cause gray platelet syndrome (GPS), characterized by the lack of platelet α-granules. This study aims to evaluate the immunological (proinflammatory) effects of platelet α-granules.</p></div><div type="abstract" xml:lang="en"><p><b>STUDY DESIGN AND METHODS</b></p><p>We performed an experiment using Nbeal2</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The lack of Nbeal2 (in Nbeal2 </p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>These results show that α-granules play a direct role in platelet-mediated inflammation balance, confirming the need to further investigate platelet-associated inflammatory pathophysiology and inflammatory adverse events related to blood transfusion.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30394544</PMID><DateCompleted><Year>2019</Year><Month>05</Month><Day>06</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-2995</ISSN><JournalIssue CitedMedium="Internet"><Volume>59</Volume><Issue>1</Issue><PubDate><Year>2019</Year><Month>01</Month></PubDate></JournalIssue><Title>Transfusion</Title><ISOAbbreviation>Transfusion</ISOAbbreviation></Journal><ArticleTitle>Platelet α-granules modulate the inflammatory response under systemic lipopolysaccharide injection in mice.</ArticleTitle><Pagination><MedlinePgn>32-38</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/trf.14970</ELocationID><Abstract><AbstractText Label="BACKGROUND">Beyond their role in hemostasis and thrombosis, platelets are also important mediators of inflammation by the release of hundreds of factors stored in their α-granules. Mutations in Nbeal2 cause gray platelet syndrome (GPS), characterized by the lack of platelet α-granules. This study aims to evaluate the immunological (proinflammatory) effects of platelet α-granules.</AbstractText><AbstractText Label="STUDY DESIGN AND METHODS">We performed an experiment using Nbeal2<sup>-/-</sup> mice, the mouse model of GPS. Systemic inflammation was induced by intravenous injection of lipopolysaccharide (LPS). Inflammatory response was assessed by quantification of inflammatory soluble factors and platelet biological response modifiers.</AbstractText><AbstractText Label="RESULTS">The lack of Nbeal2 (in Nbeal2 <sup>-/-</sup> mice, compared with controls) significantly reduced the recruitment of circulating neutrophils and monocytes. Moreover, after LPS injection, there was a significant increase in neutrophil and monocyte counts in control animals, compared with Nbeal2 <sup>-/-</sup> mice. The control of inflammation, evaluated by the production of anti-inflammatory cytokines, appeared to be greater in Nbeal2<sup>-/-</sup> mice compared with controls. Conversely, the production of certain inflammatory-soluble mediators known to characterize normal platelet secretion, such as soluble CD40 ligand (sCD40L), was decreased under experimental inflammation in Nbeal2 <sup>-/-</sup> mice.</AbstractText><AbstractText Label="CONCLUSIONS">These results show that α-granules play a direct role in platelet-mediated inflammation balance, confirming the need to further investigate platelet-associated inflammatory pathophysiology and inflammatory adverse events related to blood transfusion.</AbstractText><CopyrightInformation>© 2018 AABB.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tariket</LastName><ForeName>Sofiane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Université de Lyon, Groupe sur l'Immunité des Muqueuses et Agents Pathogènes (GIMAP)-EA3064, Saint-Etienne, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Établissement Français du Sang Auvergne-Rhône-Alpes, Saint-Etienne, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guerrero</LastName><ForeName>Jose A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Haematology, University of Cambridge and National Health Service (NHS) Blood and Transplant, Cambridge, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garraud</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><Identifier Source="ORCID">0000-0002-4102-3714</Identifier><AffiliationInfo><Affiliation>Université de Lyon, Groupe sur l'Immunité des Muqueuses et Agents Pathogènes (GIMAP)-EA3064, Saint-Etienne, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut National de la Transfusion Sanguine, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghevaert</LastName><ForeName>Cedric</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Haematology, University of Cambridge and National Health Service (NHS) Blood and Transplant, Cambridge, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cognasse</LastName><ForeName>Fabrice</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Université de Lyon, Groupe sur l'Immunité des Muqueuses et Agents Pathogènes (GIMAP)-EA3064, Saint-Etienne, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Établissement Français du Sang Auvergne-Rhône-Alpes, Saint-Etienne, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>FS/14/40/30921</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_PC_12009</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>11</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Transfusion</MedlineTA><NlmUniqueID>0417360</NlmUniqueID><ISSNLinking>0041-1132</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001798">Blood Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008070">Lipopolysaccharides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C585423">Nbeal2 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>147205-72-9</RegistryNumber><NameOfSubstance UI="D023201">CD40 Ligand</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001798" MajorTopicYN="N">Blood Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D023201" MajorTopicYN="N">CD40 Ligand</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055652" MajorTopicYN="N">Gray Platelet Syndrome</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007118" MajorTopicYN="N">Immunoassay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008070" MajorTopicYN="N">Lipopolysaccharides</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>03</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>07</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>07</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>11</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>5</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>11</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30394544</ArticleId><ArticleId IdType="doi">10.1111/trf.14970</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li><li>Royaume-Uni</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Saint-Étienne</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Tariket, Sofiane" sort="Tariket, Sofiane" uniqKey="Tariket S" first="Sofiane" last="Tariket">Sofiane Tariket</name></region><name sortKey="Cognasse, Fabrice" sort="Cognasse, Fabrice" uniqKey="Cognasse F" first="Fabrice" last="Cognasse">Fabrice Cognasse</name><name sortKey="Cognasse, Fabrice" sort="Cognasse, Fabrice" uniqKey="Cognasse F" first="Fabrice" last="Cognasse">Fabrice Cognasse</name><name sortKey="Garraud, Olivier" sort="Garraud, Olivier" uniqKey="Garraud O" first="Olivier" last="Garraud">Olivier Garraud</name><name sortKey="Garraud, Olivier" sort="Garraud, Olivier" uniqKey="Garraud O" first="Olivier" last="Garraud">Olivier Garraud</name><name sortKey="Tariket, Sofiane" sort="Tariket, Sofiane" uniqKey="Tariket S" first="Sofiane" last="Tariket">Sofiane Tariket</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Guerrero, Jose A" sort="Guerrero, Jose A" uniqKey="Guerrero J" first="Jose A" last="Guerrero">Jose A. Guerrero</name></noRegion><name sortKey="Ghevaert, Cedric" sort="Ghevaert, Cedric" uniqKey="Ghevaert C" first="Cedric" last="Ghevaert">Cedric Ghevaert</name><name sortKey="Ghevaert, Cedric" sort="Ghevaert, Cedric" uniqKey="Ghevaert C" first="Cedric" last="Ghevaert">Cedric Ghevaert</name><name sortKey="Guerrero, Jose A" sort="Guerrero, Jose A" uniqKey="Guerrero J" first="Jose A" last="Guerrero">Jose A. Guerrero</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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